ABSTRACT
Disseminated mycosis (DM)with cardiac involvement and shockis an unexpected and severe opportunistic infection in patients with yellow fever. DM can mimic bacterial sepsis and should be considered in the differential diagnosis of causes of systemic inflammatory response syndrome in this group of patients, especially in areas where an outbreak of yellow fever is ongoing. We report the case of a 53-year-old male patient who presented to the emergency department with fever, myalgia, headache, and low back pain. The laboratory investigation revealed a positive molecular test for yellow fever, hepatic injury, and renal failure. During hospitalization, the patient developed hepatic encephalopathy, ascending leukocytosis, and ascites, with signs consistent with peritonitis. On the 11th day of hospitalization, the patient developed atrioventricular block, shock and died. At autopsy, angioinvasive mycosis was evidenced mainly in the heart, lungs, kidneys, and adrenals.
Subject(s)
Humans , Male , Middle Aged , Invasive Fungal Infections/complications , Yellow Fever/complications , Autopsy , Diagnosis, Differential , Fatal Outcome , Invasive Fungal Infections/pathology , Kidney/injuries , Renal Insufficiency/complicationsABSTRACT
INTRODUCCIÓN: Las micosis invasivas agudas son infecciones rápidamente progresivas con una alta tasa de morbimortalidad. Se presentan principalmente en pacientes neutropénicos. La neutropenia puede clasificarse en cuantitativa (en neoplasias hematológicas, SIDA, inmunodepresión secundaria a transplantes) o cualitativa (en diabéticos mal controlados). Existen dos formas de presentación: Rinosinusal y extrasinusal. En esta última se describen tres subtipos: Rinoorbitaria (mayor frecuencia), rinocerebral y de partes blandas cervicofaciales. OBJETIVO: Describir dos casos clínicos de pacientes con presentaciones atípicas en las micosis invasivas agudas.
INTRODUCTION: Acute invasive mycosis can be a rapidly progressing infection that exhibits high rates of morbidity and mortality. Most commonly occurs in individuals with hematologic malignancies, particularly in patients who have received bone marrow transplantation. Other compromised patient populations at risk are those on chronic steroids, poorly controlled diabetics, patients with AIDS, and those undergoing chemoradiation therapy. Presentation forms can be rinosinusal and extrasinusal, this last one divided into: Rhinorbital, rhinocerebral and soft tissue affectation. OBJECTIVE: Describe two clinical cases of atypical presentation of acute invasive mycosis.
INTRODUÇÃO: Infecções fúngicas invasivas agudas são rapidamente progressivas, com alta taxa de morbidade e mortalidade. Eles ocorrem principalmente em pacientes neutropênicos. A neutropenia pode ser classificada como quantitativa (em neoplasias hematológicas, AIDS, imunossupressão secundária a transplantes) ou qualitativa (em diabéticos pouco controlados). Existem duas formas de apresentação: Rinossinusal e extrasinusal. Neste último, são descritos três subtipos: rino-orbitário (maior freqüência), tecido mole cervicofacial e rinocerebral. OBJETIVO: Descrever dois casos clínicos de pacientes com apresentações atípicas em micoses invasivas agudas e realizar uma revisão bibliográfica da referida patologia.